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Cover Picture: On the Way Towards Greener Transition‐Metal‐Catalyzed Processes as Quantified by E Factors (Angew. Chem. Int. Ed. 42/2013)
Author(s) -
Lipshutz Bruce H.,
Isley Nicholas A.,
Fennewald James C.,
Slack Eric D.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308153
Subject(s) - catalysis , transition metal , solvent , drop (telecommunication) , organic synthesis , cover (algebra) , coupling reaction , chemistry , organic solvent , nanotechnology , chemical engineering , materials science , organic chemistry , engineering , mechanical engineering
As E Factors drop it's a win‐win for chemistry and the environment. In their Minireview on page 10952 ff., B. H. Lipshutz and co‐workers document, by direct comparisons with transition‐metal‐catalyzed cross‐coupling reactions from pharma, just how low they can go using a commercially available designer surfactant in water as the reaction medium. As the organic solvent usage drops, E Factors can plummet by as much as an order of magnitude. Let's get organic solvents out of organic reactions, and increase sustainability.