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Cascade Reactions in Multicompartmentalized Polymersomes
Author(s) -
Peters Ruud J. R. W.,
Marguet Maïté,
Marais Sébastien,
Fraaije Marco W.,
van Hest Jan C. M.,
Lecommandoux Sébastien
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201308141
Subject(s) - polymersome , nanoreactor , polybutadiene , chemistry , enzyme , polystyrene , cofactor , cascade reaction , polymer chemistry , biophysics , combinatorial chemistry , biochemistry , copolymer , organic chemistry , polymer , biology , catalysis , amphiphile
Enzyme‐filled polystyrene‐ b ‐poly(3‐(isocyano‐ L ‐alanyl‐aminoethyl)thiophene) (PS‐ b ‐PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene‐ b ‐poly(ethylene oxide) (PB‐ b ‐PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor‐dependent three‐enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments.