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Acetylcholinesterase‐Catalyzed Hydrolysis Allows Ultrasensitive Detection of Pathogens with the Naked Eye
Author(s) -
Liu Dingbin,
Wang Zhantong,
Jin Albert,
Huang Xinglu,
Sun Xiaolian,
Wang Fu,
Yan Qiang,
Ge Shengxiang,
Xia Ningshao,
Niu Gang,
Liu Gang,
Hight Walker A. R.,
Chen Xiaoyuan
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307952
Subject(s) - naked eye , hydrolysis , computer science , sensitivity (control systems) , acetylcholinesterase , chemistry , combinatorial chemistry , nanotechnology , computational biology , enzyme , biochemistry , detection limit , biology , chromatography , materials science , engineering , electronic engineering
Seeing is believing : A rapid diagnostic platform for pathogen detection based on the acetylcholinesterase‐catalyzed hydrolysis reaction has been developed. Owing to signal amplification strategies, the sensitivity of this assay is comparable to that of PCR. In addition, the readout of the assay is based on solution color change, which can be easily observed by the naked eye alone.