Premium
Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasA p ) Bound to Synthetic Metal Complexes
Author(s) -
Shirataki Chikako,
Shoji Osami,
Terada Mitsuyoshi,
Ozaki Shinichi,
Sugimoto Hiroshi,
Shiro Yoshitsugu,
Watanabe Yoshihito
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307889
Subject(s) - heme , pseudomonas aeruginosa , chemistry , metal , biochemistry , combinatorial chemistry , stereochemistry , bacteria , enzyme , biology , organic chemistry , genetics
The heme acquisition system A protein secreted by Pseudomonas aeruginosa (HasA p ) can capture several synthetic metal complexes other than heme. The crystal structures of HasA p harboring synthetic metal complexes revealed only small perturbation of the overall HasA p structure. An inhibitory effect upon heme acquisition by HasA p bearing synthetic metal complexes was examined by monitoring the growth of Pseudomonas aeruginosa PAO1. HasA p bound to iron–phthalocyanine inhibits heme acquisition in the presence of heme‐bound HasA p as an iron source.