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Deaminative and Decarboxylative Catalytic Alkylation of Amino Acids with Ketones
Author(s) -
Kalutharage Nishantha,
Yi Chae S.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307766
Subject(s) - alkylation , chemistry , cationic polymerization , amino acid , substrate (aquarium) , ketone , cleavage (geology) , decarboxylation , functional group , combinatorial chemistry , catalysis , scope (computer science) , stereochemistry , computer science , organic chemistry , biochemistry , programming language , biology , ecology , paleontology , polymer , fracture (geology)
It cuts two ways : The cationic [Ru‐H] complex catalyzes selective coupling of α‐ and β‐amino acids with ketones to form α‐alkylated ketone products. The reaction involves CC and CN bond cleavage which result in regio‐ and stereoselective alkylation using amino acids. A broad substrate scope and high functional‐group tolerance is demonstrated.