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Effect of Pressure on the Stability of G‐Quadruplex DNA: Thermodynamics under Crowding Conditions
Author(s) -
Takahashi Shuntaro,
Sugimoto Naoki
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307714
Subject(s) - ethylene glycol , thermodynamics , volume (thermodynamics) , chemistry , molecule , crowding , dna , g quadruplex , high pressure , chemical engineering , materials science , organic chemistry , physics , biochemistry , biology , neuroscience , engineering
Under pressure : A DNA G‐quadruplex was unfolded under high pressure, but crowding conditions repressed this effect owing to enthalpic contributions. Volumetric analysis showed that ethylene glycol or poly(ethylene glycol) decreased the volume change of the transition by more than fourfold owing to the alteration of the number and/or radii of hydrating water molecules.