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A Chemical Perspective on Transcriptional Fidelity: Dominant Contributions of Sugar Integrity Revealed by Unlocked Nucleic Acids
Author(s) -
Xu Liang,
Plouffe Steven W.,
Chong Jenny,
Wengel Jesper,
Wang Dong
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307661
Subject(s) - nucleic acid , transcription (linguistics) , fidelity , dna , perspective (graphical) , computational biology , chemistry , computer science , biology , biochemistry , linguistics , telecommunications , philosophy , artificial intelligence
Transcription unlocked : A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase II (Pol II) transcription process. An unexpected dominant role for sugar‐ring integrity in Pol II transcriptional efficiency and fidelity was revealed.