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Rhodium(III)‐Catalyzed Intramolecular Hydroarylation, Amidoarylation, and Heck‐type Reaction: Three Distinct Pathways Determined by an Amide Directing Group
Author(s) -
Davis Tyler A.,
Hyster Todd K.,
Rovis Tomislav
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307631
Subject(s) - stereocenter , amide , rhodium , intramolecular force , catalysis , chemistry , carbon chain , combinatorial chemistry , group (periodic table) , stereochemistry , computer science , organic chemistry , enantioselective synthesis
The amide decides : Three different rhodium(III)‐catalyzed reaction pathways of a wide variety of tethered alkenes can be accessed through changing the amide directing group. This provides an efficient route to a myriad of complex polycyclic products, many containing newly formed all‐carbon quaternary centers. Amidoarylations can diastereoselectively deliver products with up to three contiguous stereocenters.