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Structures of Class B G Protein‐Coupled Receptors: Prospects for Drug Discovery
Author(s) -
Hausch Felix
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307542
Subject(s) - receptor , allosteric regulation , g protein coupled receptor , drug discovery , migraine , antagonist , chemistry , computational biology , pharmacology , biology , medicine , biochemistry
New members in the GPCR photo gallery! Crystal structures of class B G protein‐coupled receptors, which bind peptide hormones, have been solved [see picture of the corticotropin‐releasing factor receptor 1 (blue) and a bound allosteric nonpeptide antagonist (green)]. The structures provide a basis for a rational design of better drugs for diabetes, osteoporosis, migraine, or depression.