Premium
An Enzymatic Domain for the Formation of Cyclic Ethers in Complex Polyketides
Author(s) -
Pöplau Petra,
Frank Sarah,
Morinaka Brandon I.,
Piel Jörn
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307406
Subject(s) - champion , polyketide , conjugate , domain (mathematical analysis) , computer science , chemistry , stereochemistry , enzyme , biochemistry , computational biology , world wide web , biosynthesis , biology , mathematics , geography , mathematical analysis , archaeology
Champion cyclist : In vitro studies on the pederin biosynthetic pathway identify pyran synthases (PS) as a new family of polyketide synthase domains that stereoselectively form diverse five‐ and six‐membered ether rings by oxa‐conjugate cyclization during carbon‐chain elongation. These domains could be useful tools for chemoenzymatic synthesis.