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Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm
Author(s) -
Tao Zhimin,
Hong Guosong,
Shinji Chihiro,
Chen Changxin,
Diao Shuo,
Antaris Alexander L.,
Zhang Bo,
Zou Yingping,
Dai Hongjie
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307346
Subject(s) - ethylene glycol , nanoparticle , fluorescence , polymer , materials science , aqueous solution , molecule , photochemistry , fluorescence lifetime imaging microscopy , small molecule , chemical engineering , nanotechnology , chemistry , organic chemistry , optics , physics , engineering , biochemistry , composite material
Embedded in a polymer : A hydrophobic organic molecule that fluoresces in the near‐infrared II (NIR‐II) region was made water‐soluble and biocompatible by its embedment in a polymer nanoparticle, which was then coated with hydrophilic poly(ethylene glycol) chains. The resulting nanoparticles exhibit bright fluorescence in the NIR‐II window and high photostability in aqueous media and were used for in vivo imaging in mice.