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Bioinspired Total Synthesis of Montanine‐Type Amaryllidaceae Alkaloids
Author(s) -
Bao Xu,
Cao YeXing,
Chu WenDao,
Qu Hu,
Du JiYuan,
Zhao XianHe,
Ma XiaoYan,
Wang ChengTao,
Fan ChunAn
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307324
Subject(s) - computer science , key (lock) , computer security
Finding a common path : A synthetic strategy inspired by the proposed biogenesis of the montanine‐type alkaloids enabled the concise asymmetric synthesis of these compounds in a divergent fashion on the basis of an unprecedented tandem oxidative dearomatization/intramolecular aza‐Michael addition as the key step. This bioinspired approach revealed a chemical connection between the cherylline‐ and montanine‐type alkaloids (see scheme).