Premium
Enantioselective Copper‐Catalyzed [3+3] Cycloaddition of Azomethine Ylides with Azomethine Imines
Author(s) -
Guo Hongchao,
Liu Honglei,
Zhu FuLin,
Na Risong,
Jiang Hui,
Wu Yang,
Zhang Lei,
Li Zhen,
Yu Hao,
Wang Bo,
Xiao Yumei,
Hu XiangPing,
Wang Min
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307317
Subject(s) - cycloaddition , enantioselective synthesis , azomethine ylide , catalysis , chemistry , copper , combinatorial chemistry , yield (engineering) , organic chemistry , computer science , 1,3 dipolar cycloaddition , materials science , metallurgy
The more dipoles, the merrier : An asymmetric [3+3] cycloaddition of azomethine ylides derived from imines 1 with azomethine imines 2 in the presence of a chiral ferrocenylphosphine–copper catalyst afforded highly functionalized heterocyclic products 3 in high yield with excellent enantio‐ and diastereoselectivity (see scheme; DBU=1,8‐diazabicyclo[5.4.0]undec‐7‐ene). The 1,3‐dipolar reaction partners can be readily prepared from aldehydes.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom