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Cover Picture: Biosynthesis of the Antimetabolite 6‐Thioguanine in Erwinia amylovora Plays a Key Role in Fire Blight Pathogenesis (Angew. Chem. Int. Ed. 40/2013)
Author(s) -
Coyne Sébastien,
Chizzali Cornelia,
Khalil Mohammed N. A.,
Litomska Agnieszka,
Richter Klaus,
Beerhues Ludger,
Hertweck Christian
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307309
Subject(s) - fire blight , erwinia , pseudomonas syringae , biology , pear , bacteria , botany , guanine , microbiology and biotechnology , pathogen , biochemistry , genetics , gene , nucleotide
Fire blight , a devastating plant disease that mainly affects apple and pear trees, is caused by the bacterium Erwinia amylovora. In their Communication on page 10564 ff. C. Hertweck et al. unveil a key role of the antimetabolite 6‐thioguanine in fire blight of apple plants. Biosynthetic studies indicate that the protein YcfA mediates guanine thionation in analogy to 2‐thiouridylase. (The authors thank Nico Ueberschaar for his contribution to the cover picture.)