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Inside Cover: The Catalytically Active Copper‐Amyloid‐Beta State: Coordination Site Responsible for Reactive Oxygen Species Production (Angew. Chem. Int. Ed. 42/2013)
Author(s) -
Cassagnes LaureEstelle,
Hervé Vincent,
Nepveu Françoise,
Hureau Christelle,
Faller Peter,
Collin Fabrice
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307308
Subject(s) - copper , histidine , reactive oxygen species , redox , chemistry , int , active site , oxygen , catalysis , biochemistry , inorganic chemistry , organic chemistry , enzyme , computer science , operating system
In Alzheimer's disease, the redox‐active copper center bound to the amyloid‐beta peptide is able to produce reactive oxygen species by way of a low‐populated redox‐competent state. Insights into the coordination sphere of this state are reported by P. Faller, F. Collin, and co‐workers in their Communication on page 11110 ff. The copper atom is bound by the N‐terminal aspartate and the histidine dyad, while the third histidine acts as a gate keeper.