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An Iron/Amine‐Catalyzed Cascade Process for the Enantioselective Functionalization of Allylic Alcohols
Author(s) -
Quintard Adrien,
Constantieux Thierry,
Rodriguez Jean
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307295
Subject(s) - enantioselective synthesis , allylic rearrangement , catalysis , chemistry , nucleophile , cascade , organic chemistry , amine gas treating , surface modification , combinatorial chemistry , chromatography
Three is a lucky number : An enantioselective transformation of allylic alcohols into β‐chiral saturated alcohols has been developed by combining two distinct metal‐ and organocatalyzed catalytic cycles. This waste‐free triple cascade process merges an iron‐catalyzed borrowing‐hydrogen step with an aminocatalyzed nucleophilic addition reaction.