Frustrated Lewis Pair Catalyzed Hydroamination of Terminal Alkynes | Zendy

Mahdi Tayseer | Zendy; Stephan Douglas W. | Zendy

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Frustrated Lewis Pair Catalyzed Hydroamination of Terminal Alkynes

Author(s) -

Mahdi Tayseer,

Stephan Douglas W.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201307254

Subject(s) - hydroamination , frustrated lewis pair , chemistry , catalysis , lewis acids and bases , amine gas treating , combinatorial chemistry , stoichiometry , aryl , terminal (telecommunication) , organic chemistry , computer science , telecommunications , alkyl

Catalytic amounts of the Lewis acid B(C 6 F 5 ) 3 enable the hydroamination of terminal alkynes by aryl amines to the corresponding enamines. In accord with the results of stoichiometric reactions, the mechanism of this reaction involves a frustrated Lewis pair (FLP). The hydroamination can be followed by an FLP‐catalyzed hydrogenation, resulting in a one‐pot stepwise synthesis of amine derivatives.

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