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Frustrated Lewis Pair Catalyzed Hydroamination of Terminal Alkynes
Author(s) -
Mahdi Tayseer,
Stephan Douglas W.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307254
Subject(s) - hydroamination , frustrated lewis pair , chemistry , catalysis , lewis acids and bases , amine gas treating , combinatorial chemistry , stoichiometry , aryl , terminal (telecommunication) , organic chemistry , computer science , telecommunications , alkyl
Catalytic amounts of the Lewis acid B(C 6 F 5 ) 3 enable the hydroamination of terminal alkynes by aryl amines to the corresponding enamines. In accord with the results of stoichiometric reactions, the mechanism of this reaction involves a frustrated Lewis pair (FLP). The hydroamination can be followed by an FLP‐catalyzed hydrogenation, resulting in a one‐pot stepwise synthesis of amine derivatives.