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Directing‐Group‐Assisted Copper‐Catalyzed Olefinic Trifluoromethylation of Electron‐Deficient Alkenes
Author(s) -
Feng Chao,
Loh TeckPeng
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307245
Subject(s) - trifluoromethylation , stereospecificity , stereoselectivity , chemistry , combinatorial chemistry , acrylamide , simple (philosophy) , variety (cybernetics) , computer science , organic chemistry , catalysis , monomer , philosophy , trifluoromethyl , alkyl , polymer , epistemology , artificial intelligence
Assistance provided : The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis ‐trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β‐CF 3 ‐functionalized acrylamide derivatives.