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Back Cover: Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence‐Guided Screening of Soil Metagenomes (Angew. Chem. Int. Ed. 42/2013)
Author(s) -
Kang HahkSoo,
Brady Sean F.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307204
Subject(s) - anthracycline , int , cover (algebra) , dna , dna sequencing , natural (archaeology) , computational biology , cancer , biology , genetics , breast cancer , engineering , computer science , paleontology , mechanical engineering , operating system
Watch your step, there is new chemistry everywhere In their Communication on page 11063 ff., S. F. Brady and H.‐S. Kang describe a potent new anthracycline discovered by soil‐DNA mining methods. DNA extracted from Sonoran Desert soil (USA) was screened for gene clusters predicted to produce new natural products. The soil‐DNA‐derived arm cluster encodes arimetamycin A, an anthracycline that is active against multidrug‐resistant cancer cells and more potent than natural anthracyclines currently used in cancer therapy.