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Total Synthesis of (+)‐Asperolide C by Iridium‐Catalyzed Enantioselective Polyene Cyclization
Author(s) -
Jeker Oliver F.,
Kravina Alberto G.,
Carreira Erick M.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307187
Subject(s) - polyene , enantioselective synthesis , domino , iridium , total synthesis , world wide web , chemistry , labdane , computer science , combinatorial chemistry , catalysis , stereochemistry , diterpene , database , organic chemistry
Domino rings : A general synthetic entry into labdane‐type diterpenoids has been developed based on an iridium‐catalyzed enantioselective polyene cyclization cascade. The potential of this process is demonstrated in the first total synthesis of the tetranorlabdane diterpene asperolide C (PMB= p ‐methoxybenzyl, TMS= trimethylsilyl).