And the Winner is…︁Azadithiolate: An Amine Proton Relay in the [FeFe] Hydrogenases | Zendy

Schilter David | Zendy; Rauchfuss Thomas B. | Zendy

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And the Winner is…︁Azadithiolate: An Amine Proton Relay in the [FeFe] Hydrogenases

Author(s) -

Schilter David,

Rauchfuss Thomas B.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201307132

Subject(s) - hydrogenase , active site , chemistry , relay , amine gas treating , enzyme , combinatorial chemistry , biochemistry , physics , organic chemistry , power (physics) , quantum mechanics

A victory in the pocket : An international team of chemists and biophysicists have resolved the long‐standing question of the structure of the active site of the [FeFe] hydrogenases by assembling the active enzyme with a version of the active site synthesized in vitro (see scheme; HydF is a scaffold protein, HydA1 is a natural hydrogenase). The protein incorporating the diiron complex 2 showed similar activity to that of the natural enzyme.

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