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Nickel‐Catalyzed Sonogashira Reactions of Non‐activated Secondary Alkyl Bromides and Iodides
Author(s) -
Yi Jun,
Lu Xi,
Sun YanYan,
Xiao Bin,
Liu Lei
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201307069
Subject(s) - sonogashira coupling , alkyl , catalysis , chemistry , nickel , combinatorial chemistry , terminal (telecommunication) , computer science , organic chemistry , palladium , computer network
A nicked reaction : The title reaction of terminal alkynes with non‐activated secondary alkyl iodides and bromides was accomplished for the first time. This reaction provides a new and practical approach for the synthesis of substituted alkynes (see scheme; cod=cyclo‐1,5‐octadiene).