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Discovery of Inhibitors of the Wnt and Hedgehog Signaling Pathways through the Catalytic Enantioselective Synthesis of an Iridoid‐Inspired Compound Collection
Author(s) -
Takayama Hiroshi,
Jia ZhiJun,
Kremer Lea,
Bauer Jonathan O.,
Strohmann Carsten,
Ziegler Slava,
Antonchick Andrey P.,
Waldmann Herbert
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306948
Subject(s) - enantioselective synthesis , iridoid , wnt signaling pathway , hedgehog , hedgehog signaling pathway , chemistry , cycloaddition , stereochemistry , combinatorial chemistry , catalysis , signal transduction , biochemistry , glycoside
Cousins you can count on : An iridoid‐inspired compound collection was synthesized efficiently by the resolution of cyclic enones in an asymmetric cycloaddition with azomethine ylides. The collection contained novel potent inhibitors of the Wnt and Hedgehog signaling pathways.