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Back Cover: Rapid, Isothermal DNA Self‐Replication Induced by a Destabilizing Lesion (Angew. Chem. Int. Ed. 40/2013)
Author(s) -
Kausar Abu,
Mitran Catherine J.,
Li Yimeng,
GibbsDavis Julianne M.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306894
Subject(s) - replication (statistics) , loop mediated isothermal amplification , oligonucleotide , isothermal process , cover (algebra) , dna polymerase , dna replication , chemistry , microbiology and biotechnology , dna , biology , physics , virology , biochemistry , thermodynamics , engineering , mechanical engineering
Like clockwork, rapid isothermal self‐replication of oligonucleotides can be achieved using a cross‐catalytic strategy as reported by J. M. Gibbs‐Davis et al. in their Communication on page 10577 ff. The presence of both a destabilizing lesion in one of the replicating fragments and concentrated DNA polymerase results in high reaction rates and are key to multiple replication cycles (Photo by Dean Albrecht).