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Copper(I)‐Catalyzed Alkylation of Aryl‐ and Alkenylsilanes Activated by Intramolecular Coordination of an Alkoxide
Author(s) -
Tsubouchi Akira,
Muramatsu Daisuke,
Takeda Takeshi
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306882
Subject(s) - alkoxide , alkylation , aryl , chemistry , intramolecular force , electrophile , alkyl , halide , catalysis , medicinal chemistry , copper , organosilicon , polymer chemistry , stereochemistry , organic chemistry
Let's coordinate : Copper(I)‐catalyzed cross‐coupling of alkenyl‐ and arylsilanes with primary alkyl iodides as well as allylic and benzylic halides as C(sp 3 )X electrophilic coupling partners has been realized by intramolecular activation through alkoxide coordination. This alkylation tolerates a range of functional groups including a free hydroxy group. IPr=1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene.