Copper(I)‐Catalyzed Alkylation of Aryl‐ and Alkenylsilanes Activated by Intramolecular Coordination of an Alkoxide | Zendy

Tsubouchi Akira | Zendy; Muramatsu Daisuke | Zendy; Takeda Takeshi | Zendy

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Copper(I)‐Catalyzed Alkylation of Aryl‐ and Alkenylsilanes Activated by Intramolecular Coordination of an Alkoxide

Author(s) -

Tsubouchi Akira,

Muramatsu Daisuke,

Takeda Takeshi

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201306882

Subject(s) - alkoxide , alkylation , aryl , chemistry , intramolecular force , electrophile , alkyl , halide , catalysis , medicinal chemistry , copper , organosilicon , polymer chemistry , stereochemistry , organic chemistry

Let's coordinate : Copper(I)‐catalyzed cross‐coupling of alkenyl‐ and arylsilanes with primary alkyl iodides as well as allylic and benzylic halides as C(sp 3 )X electrophilic coupling partners has been realized by intramolecular activation through alkoxide coordination. This alkylation tolerates a range of functional groups including a free hydroxy group. IPr=1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene.

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