Premium
Recruiting Cytotoxic T Cells to Folate‐Receptor‐Positive Cancer Cells
Author(s) -
Kularatne Sumith A.,
Deshmukh Vishal,
Gymnopoulos Marco,
Biroc Sandra L.,
Xia Jinming,
Srinagesh Shailaja,
Sun Ying,
Zou Ning,
Shimazu Mark,
Pinkstaff Jason,
Ensari Semsi,
Knudsen Nick,
Manibusan Anthony,
Axup Jun Y.,
Kim Chan Hyuk,
Smider Vaughn V.,
Javahishvili Tsotne,
Schultz Peter G.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306866
Subject(s) - cytotoxic t cell , conjugate , folate receptor , antibody , chemistry , cancer cell , receptor , cancer research , microbiology and biotechnology , biology , cancer , biochemistry , immunology , in vitro , genetics , mathematics , mathematical analysis
A Fab‐ulous killer : An anti‐CD3 Fab‐folate conjugate that targets cytotoxic T cells to folate‐receptor‐positive (FR + ) tumors results in efficient killing of tumor cells by activated T cells. This chemical approach to the synthesis of bispecific antibodies using unnatural amino acids with orthogonal chemical reactivity affords homogenous conjugates with precise control over the relative geometry of the antibody binding sites in excellent yields.