Isothiourea‐Mediated One‐Pot Synthesis of Functionalized Pyridines | Zendy

Stark Daniel G. | Zendy; Morrill Louis C. | Zendy; Yeh PeiPei | Zendy; Slawin Alexandra M. Z. | Zendy; O'Riordan Timothy J. C. | Zendy; Smith Andrew D. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Isothiourea‐Mediated One‐Pot Synthesis of Functionalized Pyridines

Author(s) -

Stark Daniel G.,

Morrill Louis C.,

Yeh PeiPei,

Slawin Alexandra M. Z.,

O'Riordan Timothy J. C.,

Smith Andrew D.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201306786

Subject(s) - chemistry , thiophenol , sulfonyl , michael reaction , intermolecular force , combinatorial chemistry , polar effect , acetic acid , catalysis , organic chemistry , molecule , alkyl

Acids to bases : The synthesis of 2,4,6‐trisubstituted pyridines from (phenylthio)acetic acid and a range of α,β‐unsaturated ketimines is reported. This process proceeds by intermolecular Michael addition/lactamization, thiophenol elimination, and N‐ to O‐sulfonyl migration, giving 2‐sulfonate‐substituted pyridines which are readily derivatized to generate structural diversity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research