Highly Enantioselective Bromocyclization of Tryptamines and Its Application in the Synthesis of (−)‐Chimonanthine | Zendy

Xie Weiqing | Zendy; Jiang Guangde | Zendy; Liu Huan | Zendy; Hu Jiadong | Zendy; Pan Xixian | Zendy; Zhang Hui | Zendy; Wan Xiaolong | Zendy; Lai Yisheng | Zendy; Ma Dawei | Zendy

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Highly Enantioselective Bromocyclization of Tryptamines and Its Application in the Synthesis of (−)‐Chimonanthine

Author(s) -

Xie Weiqing,

Jiang Guangde,

Liu Huan,

Hu Jiadong,

Pan Xixian,

Zhang Hui,

Wan Xiaolong,

Lai Yisheng,

Ma Dawei

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201306774

Subject(s) - enantioselective synthesis , tryptamines , tryptamine , chemistry , combinatorial chemistry , catalysis , stereochemistry , organic chemistry , biochemistry

A shorter path : A highly enantioselective bromocyclization of tryptamine has been developed using an anionic chiral phase‐transfer catalyst. This method provides a direct approach for preparing chiral 3‐bromopyrroloindoline from tryptamine, which enables a four‐step enantioselective synthesis of (−)‐chimonanthine. PG=protecting group.

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