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A Synthetic Small Molecule for Targeted Transcriptional Activation of Germ Cell Genes in a Human Somatic Cell
Author(s) -
Han Le,
Pandian Ganesh N.,
Junetha Syed,
Sato Shinsuke,
Anandhakumar Chandran,
Taniguchi Junichi,
Saha Abhijit,
Bando Toshikazu,
Nagase Hiroki,
Sugiyama Hiroshi
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306766
Subject(s) - somatic cell , epigenome , biology , gene , germ cell , microbiology and biotechnology , germline , piwi interacting rna , genetics , genome , gene expression , transposable element , dna methylation
Germ cell gene switch : The dynamic epigenome coordinates the timely genome‐wide transcriptional activation that governs interindividual diversity, for example, in germ cells, which differ from somatic cells through their ability to undergo meiosis. Now, an epigenetically active synthetic small molecule can trigger unusual activation of the typically conserved PIWI gene that regulates the meiotic process in a human somatic cell.