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Functional Iron Oxide Magnetic Nanoparticles with Hyperthermia‐Induced Drug Release Ability by Using a Combination of Orthogonal Click Reactions
Author(s) -
N'Guyen Thuy T. T.,
Duong Hien T. T.,
Basuki Johan,
Montembault Véronique,
Pascual Sagrario,
Guibert Clément,
Fresnais Jérôme,
Boyer Cyrille,
Whittaker Michael R.,
Davis Thomas P.,
Fontaine Laurent
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306724
Subject(s) - nanoparticle , magnetic nanoparticles , click chemistry , iron oxide nanoparticles , hyperthermia , drug , iron oxide , combinatorial chemistry , chemistry , magnetic hyperthermia , materials science , nanotechnology , pharmacology , organic chemistry , medicine
Click and drug : A combination of orthogonal click reactions is employed for the preparation of functional iron oxide nanoparticles (IONPs) that show unprecedented hyperthermia‐induced drug release through a magnetically stimulated retro‐Diels–Alder (rDA) process. Magnetic stimulation induces sufficient local energy in close proximity to the cycloadduct to initiate the rDA process.