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Metal/N‐Heterocyclic Carbene Complexes: Opportunities for the Development of Anticancer Metallodrugs
Author(s) -
Cisnetti Federico,
Gautier Arnaud
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306682
Subject(s) - carbene , programmed cell death , apoptosis , chemistry , dna , metal , mitochondrion , rational design , dna damage , combinatorial chemistry , mitochondrial dna , nanotechnology , biophysics , cancer research , biochemistry , biology , materials science , organic chemistry , catalysis , gene
Death trap : The rational design of metal/N‐heterocyclic carbene complexes allows mitochondria to be targeted. Activation of several apoptotic processes (which do not include direct DNA damage) induces cell death and significant tumor suppression.