Surfactant‐Type Brønsted Acid Catalyzed Stereoselective Synthesis of  trans ‐3‐Alkenyl Indazoles from Triazenylaryl Allylic Alcohols in Water | Zendy

Yang Weijun | Zendy; Yang Zhigen | Zendy; Xu Lijun | Zendy; Zhang Lili | Zendy; Xu Xin | Zendy; Miao Maozhong | Zendy; Ren Hongjun | Zendy

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Surfactant‐Type Brønsted Acid Catalyzed Stereoselective Synthesis of trans ‐3‐Alkenyl Indazoles from Triazenylaryl Allylic Alcohols in Water

Author(s) -

Yang Weijun,

Yang Zhigen,

Xu Lijun,

Zhang Lili,

Xu Xin,

Miao Maozhong,

Ren Hongjun

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201306632

Subject(s) - stereoselectivity , pyrrolidine , chemistry , sulfonic acid , allylic rearrangement , brønsted–lowry acid–base theory , catalysis , benzene , pulmonary surfactant , organic chemistry , medicinal chemistry , polymer chemistry , biochemistry

Testing the waters : An efficient dodecyl benzene sulfonic acid (DBSA) catalyzed approach to the synthesis of the title compounds in water is reported. Furthermore, upon cleavage of the pyrrolidine group from the trans ‐3‐alkenyl‐2‐pyrrolidine‐2 H ‐indazoles with Zn in CH 3 COOH, trans ‐3‐alkenyl‐1 H ‐indazoles are obtained in good to excellent yields.

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