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A General Strategy for the Synthesis of P‐Stereogenic Compounds
Author(s) -
Berger Olivier,
Montchamp JeanLuc
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306628
Subject(s) - stereocenter , paraformaldehyde , phosphinate , hydroxymethyl , chemistry , stereochemistry , organic chemistry , enantioselective synthesis , catalysis , fire retardant
A great leap forward toward the general synthesis of P‐stereogenic compounds: Heating H 3 PO 2 with (−)‐menthol and paraformaldehyde gives easily crystallized menthyl hydroxymethyl‐ H ‐phosphinate ( 1 ). From this product, virtually any P‐stereogenic compound can be synthesized (see picture).