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Palladium‐Catalyzed Direct Functionalization of 2‐Aminobutanoic Acid Derivatives: Application of a Convenient and Versatile Auxiliary
Author(s) -
Fan Mengyang,
Ma Dawei
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306583
Subject(s) - palladium , moiety , surface modification , catalysis , glycine , combinatorial chemistry , chemistry , block (permutation group theory) , organic chemistry , amino acid , mathematics , biochemistry , geometry
New group on the block : 2‐Methoxyiminoacetyl is a readily available auxiliary for promoting palladium‐catalyzed γ arylation of C(sp 3 )H bonds. This auxiliary can be easily removed by either treatment with 1 n KOH at room temperature, or converted into a glycine moiety for peptide synthesis.