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Magnetically Triggered Dual Functional Nanoparticles for Resistance‐Free Apoptotic Hyperthermia
Author(s) -
Yoo Dongwon,
Jeong Heeyeong,
Noh SeungHyun,
Lee JaeHyun,
Cheon Jinwoo
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306557
Subject(s) - geldanamycin , apoptosis , heat resistance , heat shock protein , resistance (ecology) , dual (grammatical number) , hyperthermia , microbiology and biotechnology , hsp70 , computer science , chemistry , cancer research , materials science , biology , gene , hsp90 , biochemistry , philosophy , ecology , paleontology , composite material , linguistics
Overcoming resistance : Heat‐treated cancer cells possess a protective mechanism for resistance and survival. Resistance‐free apoptosis‐inducing magnetic nanoparticles (RAINs) successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin (GM) for heat shock protein (Hsp) inhibition under an alternating magnetic field (AMF).