Palladium‐Catalyzed Through‐Space C(sp 3 )H and C(sp 2 )H Bond Activation by 1,4‐Palladium Migration: Efficient Synthesis of [3,4]‐Fused Oxindoles | Zendy

Piou Tiffany | Zendy; Bunescu Ala | Zendy; Wang Qian | Zendy; Neuville Luc | Zendy; Zhu Jieping | Zendy

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Palladium‐Catalyzed Through‐Space C(sp 3 )H and C(sp 2 )H Bond Activation by 1,4‐Palladium Migration: Efficient Synthesis of [3,4]‐Fused Oxindoles

Author(s) -

Piou Tiffany,

Bunescu Ala,

Wang Qian,

Neuville Luc,

Zhu Jieping

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201306532

Subject(s) - palladium , catalysis , chemistry , medicinal chemistry , stereochemistry , organic chemistry

Palladium two step: Linear anilides were converted into the title compounds in good to excellent yields through a palladium‐catalyzed domino carbopalladation/1,4‐palladium shift sequence. The C(sp 3 )‐H activation involves a seven‐membered palladacycle, and is chemoselective in the presence of competitive C(sp 2 )H bonds. DMA= N , N ‐dimethylacetamide, OPiv=pivalate.

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