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Back Cover: Ligand‐Induced Conformational Changes of the Multidrug Resistance Transporter EmrE Probed by Oriented Solid‐State NMR Spectroscopy (Angew. Chem. Int. Ed. 39/2013)
Author(s) -
Gayen Anindita,
Banigan James R.,
Traaseth Nathaniel J.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306525
Subject(s) - chemistry , lipid bilayer , antiparallel (mathematics) , model lipid bilayer , crystallography , ligand (biochemistry) , solid state nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , conformational change , transporter , stereochemistry , membrane , nuclear magnetic resonance , magnetic field , biochemistry , receptor , lipid bilayer phase behavior , physics , quantum mechanics , gene
Oriented solid‐state NMR spectra in aligned bicelles with respect to the magnetic field ( B 0 ) were used to determine the asymmetric tilt angles of the membrane transporter EmrE. In their Communication on page 10321 ff., N. J. Traaseth and co‐workers show that ligand‐free EmrE forms antiparallel dimers with different monomer tilt angles relative to the lipid bilayer. Using this approach, subtle ligand‐induced conformational changes within the apo structure were also detected.