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A Practical Access to Highly Enantiomerically Pure Flavanones by Catalytic Asymmetric Transfer Hydrogenation
Author(s) -
Lemke MarieKristin,
Schwab Pia,
Fischer Petra,
Tischer Sandra,
Witt Morris,
Noehringer Laurence,
Rogachev Victor,
Jäger Anne,
Kataeva Olga,
Fröhlich Roland,
Metz Peter
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306500
Subject(s) - enantiopure drug , transfer hydrogenation , computer science , process (computing) , chemistry , scheme (mathematics) , catalysis , organic chemistry , combinatorial chemistry , enantioselective synthesis , mathematics , mathematical analysis , ruthenium , operating system
A surprisingly selective , non‐enzymatic kinetic resolution of readily available, racemic β‐chiral ketones enabled the title process, which was applied to a rapid synthesis of several bioactive flavanones in virtually enantiopure form (see scheme; MOM=methoxymethyl, Ts= p ‐toluenesulfonyl).