A Practical Access to Highly Enantiomerically Pure Flavanones by Catalytic Asymmetric Transfer Hydrogenation | Zendy

Lemke MarieKristin | Zendy; Schwab Pia | Zendy; Fischer Petra | Zendy; Tischer Sandra | Zendy; Witt Morris | Zendy; Noehringer Laurence | Zendy; Rogachev Victor | Zendy; Jäger Anne | Zendy; Kataeva Olga | Zendy; Fröhlich Roland | Zendy; Metz Peter | Zendy

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A Practical Access to Highly Enantiomerically Pure Flavanones by Catalytic Asymmetric Transfer Hydrogenation

Author(s) -

Lemke MarieKristin,

Schwab Pia,

Fischer Petra,

Tischer Sandra,

Witt Morris,

Noehringer Laurence,

Rogachev Victor,

Jäger Anne,

Kataeva Olga,

Fröhlich Roland,

Metz Peter

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201306500

Subject(s) - enantiopure drug , transfer hydrogenation , computer science , process (computing) , chemistry , scheme (mathematics) , catalysis , organic chemistry , combinatorial chemistry , enantioselective synthesis , mathematics , mathematical analysis , ruthenium , operating system

A surprisingly selective , non‐enzymatic kinetic resolution of readily available, racemic β‐chiral ketones enabled the title process, which was applied to a rapid synthesis of several bioactive flavanones in virtually enantiopure form (see scheme; MOM=methoxymethyl, Ts= p ‐toluenesulfonyl).

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