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Copper‐Mediated Synthesis of 1,2,3‐Triazoles from N ‐Tosylhydrazones and Anilines
Author(s) -
Chen Zhengkai,
Yan Qiangqiang,
Liu Zhanxiang,
Xu Yiming,
Zhang Yuhong
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306416
Subject(s) - aniline , hydrazone , combinatorial chemistry , chemistry , copper , computer science , organic chemistry
NNNifty targets : In a straightforward copper‐mediated synthesis of 1,4‐disubstituted and 1,4,5‐trisubstituted 1,2,3‐triazoles, readily available aniline and N ‐tosylhydrazone substrates underwent cyclization through CN and NN bond formation (see scheme; Piv=pivaloyl, Ts= p ‐toluenesulfonyl). This method enables the preparation of 1,2,3‐triazoles with high efficiency under mild conditions without the use of azides.