Divergent and Efficient Syntheses of the  Lycopodium  Alkaloids (−)‐Lycojaponicumin C, (−)‐8‐Deoxyserratinine, (+)‐Fawcettimine, and (+)‐Fawcettidine | Zendy

Hou SiHua | Zendy; Tu YongQiang | Zendy; Liu Lin | Zendy; Zhang FuMin | Zendy; Wang ShaoHua | Zendy; Zhang XiaoMing | Zendy

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Divergent and Efficient Syntheses of the Lycopodium Alkaloids (−)‐Lycojaponicumin C, (−)‐8‐Deoxyserratinine, (+)‐Fawcettimine, and (+)‐Fawcettidine

Author(s) -

Hou SiHua,

Tu YongQiang,

Liu Lin,

Zhang FuMin,

Wang ShaoHua,

Zhang XiaoMing

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201306369

Subject(s) - intramolecular force , lycopodium , chemistry , tricyclic , stereochemistry , condensation , thermodynamics , physics

Four from one : The four title alkaloids (structures shown in blue box) have been synthesized by using a common versatile intermediate with a 6/5/5 tricyclic skeleton. This tricyclic intermediate could be easily assembled by using an intramolecular carbene addition/cyclization and a Dieckmann condensation/Tsuji–Trost allylation as key steps.

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