Premium
Divergent and Efficient Syntheses of the Lycopodium Alkaloids (−)‐Lycojaponicumin C, (−)‐8‐Deoxyserratinine, (+)‐Fawcettimine, and (+)‐Fawcettidine
Author(s) -
Hou SiHua,
Tu YongQiang,
Liu Lin,
Zhang FuMin,
Wang ShaoHua,
Zhang XiaoMing
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306369
Subject(s) - intramolecular force , lycopodium , chemistry , tricyclic , stereochemistry , condensation , thermodynamics , physics
Four from one : The four title alkaloids (structures shown in blue box) have been synthesized by using a common versatile intermediate with a 6/5/5 tricyclic skeleton. This tricyclic intermediate could be easily assembled by using an intramolecular carbene addition/cyclization and a Dieckmann condensation/Tsuji–Trost allylation as key steps.