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Dissociation Kinetics of a Binary Complex in Solution by Protein Displacement
Author(s) -
Launay Helene,
Parent Benjamin,
Page Adeline,
Hanoulle Xavier,
Lippens Guy
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306253
Subject(s) - kinetics , displacement (psychology) , dissociation (chemistry) , computer science , binary number , chemistry , statistical physics , information retrieval , thermodynamics , physics , mathematics , psychology , arithmetic , quantum mechanics , psychotherapist
Kinetics determined by NMR : Whereas most measurements of kinetic parameters of a ligand–protein complex use displacement of the ligand, protein displacement can give accurate off‐rates in solution (see picture). Analytical and simulation results are given for the apparent off‐rate obtained by protein displacement.