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Iron‐Catalyzed Oxidative CH/CH Cross‐Coupling: An Efficient Route to α‐Quaternary α‐Amino Acid Derivatives
Author(s) -
Li Kaizhi,
Tan Guangying,
Huang Jingsheng,
Song Feijie,
You Jingsong
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306181
Subject(s) - catalysis , oxidative phosphorylation , oxidative coupling of methane , chemistry , coupling (piping) , quaternary , combinatorial chemistry , stereochemistry , organic chemistry , materials science , biochemistry , biology , paleontology , metallurgy
Fully loaded : A coordinating activation strategy has been developed to furnish α‐quaternary α‐amino acids through the iron(III)‐catalyzed oxidative functionalization of α‐C(sp 3 )H bonds of α‐tertiary α‐amino acid esters. The reaction exhibits a broad substrate scope for both α‐amino acids and nucleophiles (Nu) as well as good functional‐group tolerance (see scheme, DTBP=di‐ tert ‐butyl peroxide, DCE=1,2‐dichloroethane).