Iron‐Catalyzed Oxidative CH/CH Cross‐Coupling: An Efficient Route to α‐Quaternary α‐Amino Acid Derivatives | Zendy

Li Kaizhi | Zendy; Tan Guangying | Zendy; Huang Jingsheng | Zendy; Song Feijie | Zendy; You Jingsong | Zendy

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Iron‐Catalyzed Oxidative CH/CH Cross‐Coupling: An Efficient Route to α‐Quaternary α‐Amino Acid Derivatives

Author(s) -

Li Kaizhi,

Tan Guangying,

Huang Jingsheng,

Song Feijie,

You Jingsong

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201306181

Subject(s) - catalysis , oxidative phosphorylation , oxidative coupling of methane , chemistry , coupling (piping) , quaternary , combinatorial chemistry , stereochemistry , organic chemistry , materials science , biochemistry , biology , paleontology , metallurgy

Fully loaded : A coordinating activation strategy has been developed to furnish α‐quaternary α‐amino acids through the iron(III)‐catalyzed oxidative functionalization of α‐C(sp 3 )H bonds of α‐tertiary α‐amino acid esters. The reaction exhibits a broad substrate scope for both α‐amino acids and nucleophiles (Nu) as well as good functional‐group tolerance (see scheme, DTBP=di‐ tert ‐butyl peroxide, DCE=1,2‐dichloroethane).

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