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Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System
Author(s) -
Chen Mao,
Buchwald Stephen L.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306094
Subject(s) - trifluoromethylation , computer science , process (computing) , service (business) , chemistry , combinatorial chemistry , trifluoromethyl , aryl , broad spectrum , process engineering , organic chemistry , programming language , engineering , alkyl , economy , economics
Going to the source : The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF 3 CO 2 K as the trifluoromethyl source. The process has the advantage of short reaction times and uses convenient [CF 3 ] sources.