Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System | Zendy

Chen Mao | Zendy; Buchwald Stephen L. | Zendy

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Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System

Author(s) -

Chen Mao,

Buchwald Stephen L.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201306094

Subject(s) - trifluoromethylation , computer science , process (computing) , service (business) , chemistry , combinatorial chemistry , trifluoromethyl , aryl , broad spectrum , process engineering , organic chemistry , programming language , engineering , alkyl , economy , economics

Going to the source : The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF 3 CO 2 K as the trifluoromethyl source. The process has the advantage of short reaction times and uses convenient [CF 3 ] sources.

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