Premium
6‐Trifluoromethyl‐Phenanthridines through Radical Trifluoromethylation of Isonitriles
Author(s) -
Zhang Bo,
MückLichtenfeld Christian,
Daniliuc Constantin Gabriel,
Studer Armido
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306082
Subject(s) - trifluoromethylation , reagent , chemistry , trifluoromethyl , combinatorial chemistry , computer science , organic chemistry , alkyl
A radical approach toward 6‐perfluoroalkylphenanthridines employs the Togni reagent or derivatives thereof as radical precursors and occurs in the absence of a transition metal. Bu 4 NI is applied as radical initiator and phenanthridines are formed in good to excellent yields. In contrast to the currently intensively investigated trifluoromethylation of arenes, the arene core is formed during the trifluoromethylation in this approach.