The Catalytic Asymmetric α‐Benzylation of Aldehydes | Zendy

List Benjamin | Zendy; Čorić Ilija | Zendy; Grygorenko Oleksandr O. | Zendy; Kaib Philip S. J. | Zendy; Komarov Igor | Zendy; Lee Anna | Zendy; Leutzsch Markus | Zendy; Chandra Pan Subhas | Zendy; Tymtsunik Andrey V. | Zendy; van Gemmeren Manuel | Zendy

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The Catalytic Asymmetric α‐Benzylation of Aldehydes

Author(s) -

List Benjamin,

Čorić Ilija,

Grygorenko Oleksandr O.,

Kaib Philip S. J.,

Komarov Igor,

Lee Anna,

Leutzsch Markus,

Chandra Pan Subhas,

Tymtsunik Andrey V.,

van Gemmeren Manuel

Publication year - 2014

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201306037

Subject(s) - stereocenter , alkylation , steric effects , catalysis , chemistry , organic chemistry , proline , aldehyde , combinatorial chemistry , enantioselective synthesis , amino acid , biochemistry

The first aminocatalyzed α‐alkylation of α‐branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α‐branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α‐alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities.

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