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In Vitro and In Vivo Supramolecular Modification of Biomembranes Using a Lipidated Coiled‐Coil Motif
Author(s) -
Zope Harshal R.,
Versluis Frank,
Ordas Anita,
Voskuhl Jens,
Spaink Herman P.,
Kros Alexander
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201306033
Subject(s) - supramolecular chemistry , in vitro , computer science , in vivo , nanotechnology , membrane , coiled coil , chemistry , motif (music) , biophysics , microbiology and biotechnology , computational biology , biochemistry , materials science , biology , physics , genetics , molecule , organic chemistry , acoustics
Superficial appeal : The surface of live cells and zebrafish embryos can be modified by a supramolecular method. A peptide pair that forms a coiled coil at the cell membrane can be used to dock liposomes in in vitro and in vivo environments (see scheme). This tool can be used in biophysical studies of biological processes occurring at membranes.