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DNA as a Molecular Local Thermal Probe for the Analysis of Magnetic Hyperthermia
Author(s) -
Dias Jorge T.,
Moros María,
del Pino Pablo,
Rivera Sara,
Grazú Valeria,
de la Fuente Jesus M.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305835
Subject(s) - magnetic nanoparticles , nanoparticle , dna , magnetic field , polymer , molecule , materials science , denaturation (fissile materials) , nanotechnology , biophysics , chemistry , composite material , physics , nuclear chemistry , biochemistry , biology , organic chemistry , quantum mechanics
Too hot to handle : The surroundings of magnetic nanoparticles can be heated by applying a magnetic field. Polymer‐coated magnetic nanoparticles were functionalized with single‐stranded DNA molecules and further hybridized with DNA modified with different fluorophores. By correlating the denaturation profiles of the DNA with the local temperature, temperature gradients for the vicinity of the excited nanoparticles were determined.