Premium
Palladium(II)‐Catalyzed Intramolecular Hydroamination of 1,3‐Dienes to Give Homoallylic Amines
Author(s) -
Pierson Justin M.,
Ingalls Erica L.,
Vo Richard D.,
Michael Forrest E.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305766
Subject(s) - hydroamination , pincer movement , palladium , intramolecular force , chemistry , amine gas treating , catalysis , combinatorial chemistry , regioselectivity , ligand (biochemistry) , amination , medicinal chemistry , organic chemistry , biochemistry , receptor
A pincer for high selectivity : A mild palladium‐catalyzed hydroamination of protected amino‐1,3‐dienes is possible. This highly regioselective reaction employs a tridentate PNP pincer ligand and leads to cyclic and homoallylic protected amines in high yields. Substrates with a wide array of amine protecting groups and diene substitution patterns were cyclized to form five‐ and six‐membered heterocycles. PG=protecting group.