Palladium(II)‐Catalyzed Intramolecular Hydroamination of 1,3‐Dienes to Give Homoallylic Amines | Zendy

Pierson Justin M. | Zendy; Ingalls Erica L. | Zendy; Vo Richard D. | Zendy; Michael Forrest E. | Zendy

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Palladium(II)‐Catalyzed Intramolecular Hydroamination of 1,3‐Dienes to Give Homoallylic Amines

Author(s) -

Pierson Justin M.,

Ingalls Erica L.,

Vo Richard D.,

Michael Forrest E.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201305766

Subject(s) - hydroamination , pincer movement , palladium , intramolecular force , chemistry , amine gas treating , catalysis , combinatorial chemistry , regioselectivity , ligand (biochemistry) , amination , medicinal chemistry , organic chemistry , biochemistry , receptor

A pincer for high selectivity : A mild palladium‐catalyzed hydroamination of protected amino‐1,3‐dienes is possible. This highly regioselective reaction employs a tridentate PNP pincer ligand and leads to cyclic and homoallylic protected amines in high yields. Substrates with a wide array of amine protecting groups and diene substitution patterns were cyclized to form five‐ and six‐membered heterocycles. PG=protecting group.

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