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Bone‐Crack Detection, Targeting, and Repair Using Ion Gradients
Author(s) -
Yadav Vinita,
Freedman Jonathan D.,
Grinstaff Mark,
Sen Ayusman
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305759
Subject(s) - computer science , service (business) , nucleic acid , chemistry , business , biochemistry , marketing
Bone cracks can be detected by utilizing the damaged matrix itself as both the trigger and the fuel. A crack in a material with a high mineral content such as bone generates ion gradients, which can be utilized for active targeting and treatment. This approach to targeting a biological structure augments current methods, which are focused on biomacromolecular interactions involving proteins and nucleic acids.