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Targeted Bioimaging and Photodynamic Therapy Nanoplatform Using an Aptamer‐Guided G‐Quadruplex DNA Carrier and Near‐Infrared Light
Author(s) -
Yuan Quan,
Wu Yuan,
Wang Jie,
Lu Danqing,
Zhao Zilong,
Liu Tao,
Zhang Xiaobing,
Tan Weihong
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305707
Subject(s) - aptamer , photodynamic therapy , photosensitizer , phototoxicity , photon upconversion , g quadruplex , nanotechnology , chemistry , materials science , dna , optoelectronics , photochemistry , microbiology and biotechnology , luminescence , biology , biochemistry , in vitro , organic chemistry
Target practice : A novel photodynamic therapy system has been constructed by taking advantage of the specific molecular recognition of an aptamer, loading capability of a G‐quadruplex, and upconversion of nanoparticles using near‐infrared (NIR) light. This system selectively delivers a photosensitizer to targeted cells and upon irradiation with NIR light demonstrates phototoxicity effects.